Besides hCG, which marker can be positive in seminoma?

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Multiple Choice

Besides hCG, which marker can be positive in seminoma?

Explanation:
Marker profile in seminoma includes hCG and PLAP; besides hCG, placental alkaline phosphatase can be positive. PLAP is an enzyme expressed by germ cell tumor cells, particularly seminomas, and it shows up on serum tests and tissue staining, helping support the diagnosis when seminoma is suspected. LDH can be elevated and may reflect tumor burden, but it’s nonspecific. AFP is typically not elevated in pure seminoma (more common in yolk sac tumors and other nonseminomatous components), and CA125 is not a relevant marker for testicular germ cell tumors. So, PLAP is the classic additional marker that can be positive in seminoma.

Marker profile in seminoma includes hCG and PLAP; besides hCG, placental alkaline phosphatase can be positive. PLAP is an enzyme expressed by germ cell tumor cells, particularly seminomas, and it shows up on serum tests and tissue staining, helping support the diagnosis when seminoma is suspected. LDH can be elevated and may reflect tumor burden, but it’s nonspecific. AFP is typically not elevated in pure seminoma (more common in yolk sac tumors and other nonseminomatous components), and CA125 is not a relevant marker for testicular germ cell tumors. So, PLAP is the classic additional marker that can be positive in seminoma.

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